WebINTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; 180680) and U2 (RNU2; 180690) ( Baillat et al., 2005 ). WebMouse insertional mutagenesis experiments support the designation of INTS4 as a cancer causing gene. This gene does not have a cancer hallmark. You can see more information about hallmarks. INT4, MGC16733, MST093, CCDS31644.1, Q96HW7, ENSG00000149262.16, NM_033547.3, NP_291025. There are 3 structures for INTS4 .
INTS4 integrator complex subunit 4 [ (human)] - National Center …
WebOct 31, 2006 · INTS4: 852: Sequence caution The sequence AAQ13616.1 differs from that shown. Reason: Miscellaneous discrepancy Probable cloning artifact. Curated. Features. Showing features for alternative sequence, sequence conflict. Type. ID Position(s) Description; Alternative sequence: VSP_021448: WebDec 13, 2024 · Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14 (PubMed:23097424).Within the complex, interacts with IntS12 and IntS9 (PubMed:23288851).Interaction with IntS12 is likely to be important for promoting 3' … puritan phonograph
Structure of the catalytic core of the Integrator complex
WebINTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]). ... WebFeb 20, 2024 · Human INTS4, INTS9 and INTS11 were coexpressed in insect cells using Multibac technology (Geneva Biotech) . INTS4 carried an N-terminal hexa-histidine-tag, while INTS9 and INTS11 were untagged. High5 cells were grown in ESF 921 medium (Expression Systems) by shaking at 120 rpm at 27°C until the density reached 1.5–2 × 10 6 cells ml −1. WebMar 21, 2024 · INTS4 (Integrator Complex Subunit 4) is a Protein Coding gene. Diseases associated with INTS4 include Leigh Syndrome . Among its related pathways are Gene expression (Transcription) and Formation of HIV elongation complex in the absence of HIV Tat . Gene Ontology (GO) annotations related to this gene include binding . sections of it act 2000