Definition of platelet refractoriness
WebOct 1, 2024 · Platelet transfusion refractoriness (PTR) is defined as the repeated failure to appropriately increment platelet count after platelet transfusions [1] and is encountered in up to 30% of patients that have a hematological disease [2]. The etiologies of PTR can be schematically separated into immune and non-immune causes (splenomegaly, fever ... WebDec 30, 2024 · Platelets stick together, helping blood to form a clot that stops bleeding when you damage a blood vessel, such as when you cut yourself. Thrombocytosis occurs when your body produces too many platelets. Reactive thrombocytosis. This is the more common type of thrombocytosis. It's caused by an underlying medical problem, such as:
Definition of platelet refractoriness
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WebMay 6, 2024 · Platelet transfusion refractoriness (PTR) is common in patients with hematology and oncology and is becoming an important barrier in the treatment of thrombocytopenia and hemorrhage. Bibliometrics is an effective method for identifying existing research achievements, important breakthroughs, current research hotspots, … WebJul 20, 2015 · Definition. Platelet refractoriness can represent a significant clinical problem that complicates provision of platelet transfusions, and which may be …
WebSep 23, 2024 · Irrespective of the underlying etiology, platelet transfusion refractoriness is a clinically important problem in the ICU. It has been associated with increased complications and mortality [8, 13].However, there is paucity of studies on the prevalence and clinical significance of platelet refractoriness in the ICU setting. WebArrhythmogenic cardiomyopathy (ACM) is a genetically determined myocardial disease, characterized by myocytes necrosis with fibrofatty substitution and ventricular arrhythmias that can even lead to sudden cardiac death. The presence of inflammatory cell infiltrates in endomyocardial biopsies or in autoptic specimens of ACM patients has been reported, …
WebMay 12, 2024 · Definition – Platelet refractoriness is defined as a platelet count increment less than expected after at least two platelet transfusions. Quantitative … WebThe percentage agreement between common definitions of refractoriness was calculated based on these parameters. As the maintenance of platelet counts above 20 x 10(9)/l is …
WebSep 22, 2016 · An International Working Group (IWG) defined refractory ITP as disease that does not respond to or relapses after splenectomy and that requires treatment to reduce the risk of clinically significant bleeding. 2 The American Society of Hematology ITP Guidelines endorsed this definition as a means of identifying the most severely affected ...
WebWith the growing number of medical options, substantially fewer patients are becoming “refractory.” These advances mandate reassessment of the following conceptual definitions and goals in the treatment of ITP: disease phases, treatment response, remission, refractory, treatment goals and acceptable target platelet levels. laminarjiWebMar 15, 2024 · We confirmed platelet refractoriness more frequently in cases than in controls (p = 0.0005). Compared with human leukocyte antigen-matched sibling donors, alternative donors were significantly more prone to cytomegalovirus retinitis (p = 0.0009). ... Exposures and Definition. Thirteen pre-transplant parameters were chosen to compare … lamina rossaWebThe 2 most common causes of alloimmune refractoriness to platelets are antibodies to foreign human leukocyte antigens (HLA), and human platelet antigens (HPA). … laminar fountain kitlamina okiWebData regarding the efficacy of rFVIIa in patients with GT and platelet refractoriness are available from a large patient registry, an international survey, and multiple case reports … assassin's rogueWebOct 3, 2024 · Background. Platelet refractoriness represents a serious complication in platelet-transfusion-dependent patients. It is associated with adverse clinical outcomes, such as increased bleeding risk, and decreased survival and increased health care costs due to increased length of stay. 1-3 Following platelet transfusion, the effectiveness of … laminarkiWebApr 1, 2024 · Download Citation On Apr 1, 2024, Tatiana Fernández-Barge and others published EXTENDED PLATELET TRANSFUSION IN BLEEDING PATIENTS WITH PLATELET TRANSFUSION REFRACTORINESS Find, read and cite ... laminas assa